The oddest couple takes an unforgettable journey through the American Southwest, finding happiness in the unlikeliest of places and seeing in each other what no one else has seen before. Maya (Willis) is a product of childhood abuse who escapes her shattered life in Los Angeles and meets Duncan (Marquette), a hermit from a tiny town. He is socially awkward and a slave to pattern and routine, but a master of map-making and directions. Their journey teaches Maya to care for someone else and takes Duncan into a new world. Their road trip is filled with unexpected surprises and hard realities that redefine the notion of family.